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The Duke Blue Devils will try to beat the relentless Houston Cougars defense on Saturday night in the Final Four. Can Emanual Sharp and the Cougars slow down Tyrese Proctor and the Blue Devils tonight? Next Level Bets is expecting a defensive battle in this Houston vs. Duke Final Four pick.
ANALYSIS

Houston vs. Duke Final Four Picks: Expert Prediction, Latest March Madness Odds for Cougars vs. Blue Devils

We’ve got a huge showdown tonight in the Final Four as Duke and Houston face off in what’s expected to be one of the best matchups of the tournament. Both of these teams have been dominant all season, and tonight should be no different. Let’s break it all down and find the best value on the board!

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Houston vs. Duke Odds

  • Moneyline: Houston +225, Duke -250
  • Spread: Houston +4.5 (-110), Duke -4.5 (-110)
  • Total: Over 136.5 (-115), Under 136.5 (-105)

Houston vs. Duke Date, Time, and Where to Watch

  • Date: Saturday, April 5, 2025
  • Game Time: 8:49 PM ET
  • Where to Watch: CBS

Click here for latest Houston vs. Duke Odds

Houston vs. Duke Prediction

This is a true clash of styles. Duke comes in with one of the most explosive offenses in the country—they’ve proven all year long that they can score on just about anyone. But tonight, they go up against a Houston squad known for its elite defense, physical play, and ability to control the tempo.

Houston’s defense will challenge Duke more than most teams have, but on the flip side, Houston’s offense has been inconsistent at times and struggles to keep up when the pace picks up. Both teams are going to bring high-level defense in this one, and the pressure of the Final Four stage should slow the game down even more.

This has all the makings of a defensive grind—it wouldn’t be surprising to see both teams locked in a tight, low-scoring battle. The under looks like the sharpest angle with two elite defenses and high stakes on the line.

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