Champions League Odds, Predictions, and Best Bets for Real Madrid, Barcelona Quarterfinal Matches

The second leg of the 2024-25 UEFA Champions League Quarter-Finals are set to kick off on Tuesday and Wednesday. In this Champions League betting preview, we'll focus on upcoming matches between Barcelona vs. Dortmund and Real Madrid vs. Arsenal.

Matt MacKay is back with a pair of picks to tail ahead of the second leg of the UEFA Champions League Quarter-Finals. Follow Matt's X account for more betting analysis and free picks.

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BORUSSIA DORTMUND VS. BARCELONA ODDS

• Home: Borussia Dortmund (+250)
• Tie: (+350)
• Away: Barcelona (-105)

BORUSSIA DORTMUND VS. BARCELONA DATE, TIME, AND WHERE TO WATCH

• Date: Tuesday, April 15, 2025
• Time: 3:00 PM ET
• How to Watch: Paramount+

Click here for complete Dortmund vs. Barcelona Odds

BORUSSIA DORTMUND VS. BARCELONA PREDICTION

Barcelona dominated Dortmund during the first leg, beating them 4-0 on their home pitch. As a result, Dortmund is forced to be aggressive on offense early in Tuesday's match due to Barcelona leading this Quarter-Finals series with an aggregate score of 4-0.

Despite holding a 4-0 lead, oddsmakers still favor Barcelona to win the second leg match on the road in Dortmund today. It could be due to Barcelona starting two double-digit goal scorers, Raphina and Robert Lewandowksi, who have combined for 23 goals during Champions League play.

Neither side in this match is dealing with key injuries, so it's going to be up to Serhou Guirassy and company to find a way to gain momentum through a couple of early scores against Barcelona. Unfortunately for Dortmund, Barcelona has surrendered just one goal in its last three matches played.

Dortmund has scored a total of three goals across its last four matches. We can either bet on Barcelona to win this match, despite holding a 4-0 lead, at -105 odds. Or, we can bet on a goal total market.

Dortmund's going to be aggressive early at home but Barcelona's defense is stout and they'll be able to counter and play keep away. I don't think we see more than three goals scored in this match, especially with Dortmund's inconsistent offense. Let's bet a unit on under 3.5 total goals at -122 odds between Dortmund and Barcelona.

BORUSSIA DORTMUND VS. BARCELONA PICK

• Pick: Under 3.5 Total Goals (-122) Click here to see which sportsbook has the best Dortmund vs. Barcelona Odds

REAL MADRID VS. ARSENAL ODDS

• Home: Real Madrid (-140)
• Tie: (+320)
• Away: Arsenal (+380)

REAL MADRID VS. ARSENAL DATE, TIME, AND WHERE TO WATCH

• Date: Wednesday, April 16, 2025
• Time: 3:00 PM ET
• How to Watch: Paramount+

Click here for complete Real Madrid vs. Arsenal Odds

REAL MADRID VS. ARSENAL PREDICTION

Wednesday's marquee matchup features Real Madrid against Arsenal. Despite boasting one of the most impressive rosters in the Champions League, Real Madrid lost the first leg to Arsenal, 3-0, so they'll have to rally early to erase this three-goal deficit to improve their chances of advancing to the Champions League Semi-Finals.

One of Arsenal's top scorers, Kai Havertz, is injured and won't be available to play against Real Madrid on Wednesday. They still have Declan Rice and Bukayo Saka with eight combined goals.

Real Madrid is healthier in comparison to Arsenal. They've looked dominant since 2025 began, recording five consecutive wins before losing their last two games to Atletico Madrid and Arsenal. The 1-0 loss to cross-town rival, Atletico Madrid, wasn't a big deal due to winning the series 2-1 on aggregate. However, Real Madrid is down 3-0 heading into the second leg of their series against Arsenal tonight.

Kylian Mbappé and Vinícius Júnior each have seven goals scored in Champions League play thus far. Real Madrid will run their offense through these two to generate early scoring opportunities. Arsenal's a tough defense to crack, allowing four total goals across their last six Champions League matches.

Playing at home helps Real Madrid quite a bit. They'll look to score early to gain some momentum against Arsenal, who will likely cling to their 3-0 aggregate lead, attempting to melt the clock and control time of possession.

There's too much talent on this Real Madrid roster to ignore. Let's drink the juice and bet a unit on Real Madrid to win this second Quarter-Finals match against Arsenal playing at home in Santiago Bernabéu.

REAL MADRID VS. ARSENAL PICK

• Pick: Real Madrid Moneyline (-140) Click here to see which sportsbook has the best Real Madrid vs. Arsenal Odds